Comedy TV shows premiered in 2021
- Clarkson's Farm (2021-)
- The White Lotus (2021-)
- Ghosts (2021-)
- Only Murders in the Building (2021-)
- Only Murders in the Building (2021-)
- Abbott Elementary (2021-)
- Hacks (2021-)
- WandaVision (2021-2021)
- Resident Alien (2021-2025)
- It's a Sin (2021-2021)
- As If (2021-2025)
Original title: Gibi - The Sex Lives of College Girls (2021-2025)
- Ginny & Georgia (2021-)
- Reservation Dogs (2021-2023)
- Fisk (2021-)
- Acapulco (2021-2025)
- Inside Job (2021-2022)
- Hometown Cha-Cha-Cha (2021-2021)
Original title: Gaetnaeul Cha Cha Cha - Dhindora (2021-)
- Chucky (2021-2024)
- We Are Lady Parts (2021-)
- Wagle Ki Duniya (2021-)
Original title: वागले की दुनिया - The Outlaws (2021-)
- Physical (2021-2023)
- Ranking of Kings (2021-2022)
Original title: 王様ランキング - Decoupled (2021-2021)
- Dug Days (2021-2021)
- Mr. Queen: The Bamboo Forest (2021-2021)
Original title: Cheolinwanghoo: Daenamusup - Pretend It's a City (2021-2021)
- Our Beloved Summer (2021-2022)
Original title: Geu hae urineun - Men in Kilts: A Roadtrip with Sam and Graham (2021-2023)
- Schmigadoon! (2021-2023)
- The Ms. Pat Show (2021-)
- Bad Buddy (2021-2022)
- Bump (2021-2024)
- The Chair (2021-2021)
- Vincenzo (2021-2021)
Original title: Binsenjo - Young Rock (2021-2023)
- Odd Taxi (2021-2021)
- Starstruck (2021-2023)
- Ten Year Old Tom (2021-2023)
- Big Shot (2021-2022)
- The Mysterious Benedict Society (2021-2022)
- Girls5eva (2021-)
- Harlem (2021-2025)
- Cowboy Bebop (2021-2021)
- Horimiya (2021-2021)
Original title: Hori-san to Miyamura-kun - Around the World in 80 Days (2021-2021)
- The Shrink Next Door (2021-2021)
- Monsters at Work (2021-)
- The Big Leap (2021-2021)
- The Cleaner (2021-)
- Family Law (2021-)
- Falling Into Your Smile (2021-)
Original title: 你微笑时很美 - Komi Can't Communicate (2021-2022)
Original title: 古見さんは、コミュ症です。 - The Great North (2021-2025)
- The Ghost and Molly McGee (2021-2024)
- Tear Along the Dotted Line (2021-2021)
Original title: Strappare lungo i bordi - Trailer Park Boys: Jail (2021-2025)
- SK8 the Infinity (2021-)
Original title: SK8 - Pernille (2021-)
Original title: Pørni - The Mighty Ducks: Game Changers (2021-2022)
- Stay Close (2021-2021)
- Centaurworld (2021-2021)
- Bad and Crazy (2021-2022)
- Gabby's Dollhouse (2021-)
- Landscapers (2021-2021)
- Made for Love (2021-2022)
- Kevin Can F**K Himself (2021-2022)
- MacGruber (2021-2021)
- My Roommate Is a Gumiho (2021-2021)
Original title: Gan Tteoleojineun Donggeo - Sort Of (2021-2024)
- F4 Thailand: Boys Over Flowers (2021-2022)
Original title: หัวใจรักสี่ดวงดาว - Pôr do Sol (2021-2022)
- Generation (2021-2021)
Original title: Genera+ion - Bill Burr Presents Immoral Compass (2021-2021)
- Olaf Presents (2021-2021)
- Alpha Betas (2021-2023)
- Dali and the Cocky Prince (2021-2021)
Original title: Dalriwa Gamjatang - Yumi's Cells (2021-2022)
Original title: Yumieui Sepodeul - The Upshaws (2021-)
- Running Errands (2021-2024)
Original title: Ayak Isleri - Penguin Town (2021-2021)
- HPI Haut Potentiel Intellectuel (2021-)
Original title: HPI - Home Economics (2021-2023)
- With Love (2021-2023)
- Higehiro: After Being Rejected, I Shaved and Took in a High School Runaway (2021-2021)
Original title: Hige o Soru. Soshite Joshikousei o Hirou. - You are My Glory (2021-2021)
Original title: Ni shi wo de rong yao - Grand Crew (2021-2023)
- Under the Vines (2021-)
- That Damn Michael Che (2021-2022)
- My Love Mix-Up! (2021-2021)
- The Problem with Jon Stewart (2021-2023)
- The Club (2021-2023)
Original title: Kulüp - Mixte (2021-2021)
- Expedition: Back to the Future (2021-2021)
- Die Discounter (2021-2024)
- iCarly (2021-2023)
- Doogie Kamealoha, M.D. (2021-2023)
- Daughter from Another Mother (2021-2022)
Original title: Madre solo hay dos - Mad for Each Other (2021-2021)
Original title: Yi Guyeokui Michin X - Pretty Hard Cases (2021-2023)
- Family Matter (2021-2024)
- Painting with John (2021-2023)
- The Croods: Family Tree (2021-2023)
- Gutfeld! (2021-2025)
- Central Russia's Vampires (2021-2025)
Original title: Vampiry sredney polosy - The Way of the Househusband (2021-2023)
Original title: Gokushufudo - Saturday Morning All Star Hits! (2021-2021)
- Love Scenery (2021-2021)
Original title: 良辰美景好时光 - Country Comfort (2021-2021)
- Sell Your Haunted House (2021-2021)
Original title: 대박부동산 - The Wonder Years (2021-2023)
- Tuttle Twins (2021-)
- Sunflower (2021-)
- Bloods (2021-2022)
- Ziwe (2021-2022)
- Ja, Chef (2021-)
- Sex/Life (2021-2023)
- The Crew (2021-2021)
- Frankelda's Book of Spooks (2021-2021)
Original title: Los sustos ocultos de Frankelda - Tschugger (2021-2024)
- Toon in with Me (2021-)
- Rutherford Falls (2021-2022)
- How a Realist Hero Rebuilt the Kingdom (2021-2022)
Original title: 現実主義勇者の王国再建記 - Mr. Corman (2021-2021)
- So I Married My Anti-Fan (2021-2021)
Original title: Geuraeseo Naneun Antipaengwa Gyeolhonhaetda - Turner & Hooch (2021-2021)
- The Premise (2021-2021)
- LOL: Last One Laughing Germany (2021-)
Original title: LOL: Last One Laughing - American Auto (2021-2023)
- Mr. Mayor (2021-2022)
- Frank of Ireland (2021-2021)
- Kotaro Lives Alone (2021-2023)
- Creamerie (2021-)
- Russell Howard: Lubricant (2021-2021)
- The Barbarian and the Troll (2021-2021)
- Pixar Popcorn (2021-2021)
- DON'T TOY WITH ME, MISS NAGATORO (2021-2023)
Original title: イジらないで、長瀞さん - Mieruko-chan (2021-2021)
- Masameer County (2021-)
- So I'm a Spider, So What? (2021-2021)
Original title: 蜘蛛ですが、なにか？ - HouseBroken (2021-2023)
- Normal British Series (2021-2022)
- Marvel's M.O.D.O.K. (2021-2021)
- Unforgettable Love (2021-2021)
Original title: 贺先生的恋恋不忘 - The Now (2021-2021)
- United States of Al (2021-2022)
- The Bite (2021-2021)
- And Just Like That… (2021-2025)
- Life's Punchline (2021-2021)
Original title: Konto ga hajimaru - History of Swear Words (2021-2021)
- The Larkins (2021-2022)
- Poorly Drawn Lines (2021-2021)
- Elliott from Earth (2021-2021)
- The Unusual Suspects (2021-2021)
- Punky Brewster (2021-2021)
- Mammoth (2021-)
- The Cheap Seats (2021-)
- My Senpai Is Annoying (2021-2021)
Original title: Senpai ga Uzai Kouhai no Hanashi - Blindspotting (2021-2023)
- Work Later, Drink Now (2021-2023)
Original title: Soolkkundoshiyeojadeul - 50M² (2021-2021)
- Elvira's 40th Anniversary, Very Scary, Very Special, Special (2021-2021)
- Jellystone (2021-)
Original title: Jellystone! - Johnson (2021-)
- Susah Sinyal: The Series (2021-2022)
- Flatbush Misdemeanors (2021-2022)
- UFOs (2021-2022)
Original title: OVNI(s) - Cutting (2021-)
- Wolfboy and the Everything Factory (2021-)
- Fish Upon the Sky (2021-2021)
Original title: Pla bon fah - Sunny Beach (2021-)
Original title: Съни бийч - Once We Get Married (2021-2021)
Original title: Zhi Shi Jie Hun De Guan Xi - The Diary of the Great Perica (2021-2024)
Original title: Dnevnik velikog Perice - Gintama: The Semi-Final (2021-2021)
Original title: 銀魂 THE SEMI-FINAL - Dogu (2021-)
- Run the World (2021-2023)
- Pretty Smart (2021-2021)
- Be Loved in House (2021-2021)
- Millennials (2021-)
- Kenan (2021-2022)
- Aftertaste (2021-2022)
- Shanti Kranti (2021-)
Original title: Shantit Kranti - Imitation (2021-2021)
Original title: Imiteisyeon - Welcome to Utmark (2021-)
Original title: Velkommen til Utmark - I Literally Just Told You (2021-)
- Secret Royal Inspector & Joy (2021-2021)
Original title: 어사와 조이 - Moonshine (2021-)
- Life Lessons with Uramichi Oniisan (2021-2021)
Original title: Uramichi Oniisan - LOL: Last One Laughing Italy (2021-)
Original title: LOL - Chi ride è fuori - Back to the Rafters (2021-2021)
- Bridge Kids (2021-)
- The Game (2021-2023)
- A Wonderful Sight (2021-2021)
Original title: Gukyeongi - Princípio, Meio e Fim (2021-2021)
- Just Beyond (2021-2021)
- Tom and Jerry in New York (2021-2021)
- Bottom-Tier Character Tomozaki (2021-2024)
Original title: Jaku-chara Tomozaki-kun - The Duke of Death and His Maid (2021-2024)
Original title: Shinigami Bocchan to Kuro Maid
